PATH2XNAT- XNAT and GALAXY based platform for accelerated research on the pathogenesis of infectious diseases

Duration of the project: November 2023 - July 2025

Many SARS-CoV-2 patients in intensive care were presented with hypercoagulation causing fatal thrombosis. Analysis of SARS-CoV-2 infected lungs revealed post-infection immunological responses. Further research on the interactions between SARS-CoV-2 and its receptors has led to novel prevention and treatment strategies. To accelerate such research on the pathogenesis in other infectious diseases, a streamlined data management and analysis platform is needed.

The aim of this project is to develop a data management and analysis platform, called PATH2XNAT https://bigr.nl/project/path2xnat/, built on top of existing platforms XNAT and Galaxy (Galaxy is an open-source bioinformatics workflow platform, supported by ELIXIR-NL, which has been used for automated SARS-CoV-2 genome surveillance (https://www.infectious-diseases-toolkit.org/showcase), to accelerate research on the pathogenesis of infectious diseases.